We are advancing three late-stage cardiovascular therapies in indications for which no approved therapies currently exist.

Fueled by deep scientific expertise and a passion for helping people with cardiovascular diseases, Kardigan has curated a robust pipeline of late-stage clinical programs, each designed to move beyond symptom management and to redefine treatment approaches where patients and their families need it most.

Program
Lead Indication
Mechanism of Action
Phase
Lead Indication
Genetic Dilated Cardiomyopathy
Mechanism of Action
Direct Myosin Activator
Phase
Phase 2b/3
Program
Ataciguat2
Lead Indication
Moderate Calcific Aortic Valve Stenosis
Mechanism of Action
Soluble Guanylyl Cyclase Activator
Phase
Phase 2b
Lead Indication
Acute Severe Hypertension
Mechanism of Action
Angiotensinogen ASO
Phase
Phase 2b

1 Kardigan in-licensed exclusive worldwide development and commercialization rights to danicamtiv, an investigational drug discovered at MyoKardia and further developed by Bristol Myers Squibb.
2 Kardigan acquired rights to ataciguat, an investigational drug developed by, and in-licensed from, Sanofi and Mayo Clinic.
3 Kardigan in-licensed exclusive worldwide development and commercialization rights to tonlamarsen, an investigational drug discovered and developed by Ionis.